Vacancies

Associate Principal Scientist DMPK

Please Note: The application deadline for this job has now passed.

Job Introduction

Associate Principal Scientist - DMPK

At Pharmaron we offer:

Vibrant and dynamic employment – we are a highly specialised, growth company operating in a critical sector of the economy – our future is strong and exciting!
Opportunities to develop your skills and yourself – our rapid growth brings greater opportunities for you to learn and grow faster!
A great team where we all support each other – enjoy your work – after all you spend about a third of your time here!

Requirements:

BSc or higher in relevant scientific discipline, pharmacology, pharmaceutical sciences
Experience of working in DMPK drug discovery and/or development projects with appreciation of related disciplines
Working knowledge of multiple DMPK/ADME assays
Experience of applying DMPK science to small molecule drug discovery/development projects
Expertise in trouble shooting problems with DMPK/ADME assays
Robust mechanistic knowledge and application of PK and ADME and principles and how this relates to drug behavior

Key roles and responsibilities:

To provide PK and ADME study design, results interpretation and reporting in support of multiple small molecule projects with the Pharmaron Drug Discovery department to ensure continued project and contract delivery to our partners and to enhance the scientific reputation of Pharmaron with its scientific and commercial stakeholders.
Provide technical direction and applying innovation to problem solving in projects across the Drug Discovery organization within own area of expertise.
Conduct human PK, dose predictions and using routine approaches and including PBPK as appropriate using available software
Collate and interpretation of results from the PK and ADME teams within the Pharmaron organization and further analyse/model/simulate in the context of the project aims.
Ensure the smooth operation and scheduling of the DMPK screening strategy for the matrix drug discovery teams internal to PDDSE and external with clients.
Maintenance and presentation of IVIVE and SAR for ADME properties to high standard.
Provide quality data, written reports and presentations internally and to our partners to ensure regular progress updates and client satisfaction.
Able to act as point of contact and manage client interactions for specified parts of an integrated project
The role requires meticulous attention to detail and for all work to be conducted strictly in accordance with company Policies and Procedures and Standard Operating Procedures.

Pharmaron Integrated Drug Discovery

The Drug Discovery department, based in Hoddesdon, Hertfordshire, UK provides world-class drug discovery leadership to our partners in the life-science industry. As trusted collaborators, and in synergy with the capabilities and resources of the global Pharmaron group, this multi-disciplinary science team delivers quality, small-molecule preclinical candidates across a diversity of therapeutic areas and routes of administration. With a track record of delivering small molecules to the candidate nomination milestone and the clinic the experienced Hoddesdon team provides leadership, strategy, molecule design and project oversight. This expertise coupled with the extensive capabilities of Pharmaron worldwide platforms for experimental delivery has created a unique and exciting business model.

With a rapidly expanding department and portfolio the Drug Discovery DMPK function is seeking individuals who have a passion for leading DMPK science in discovery projects and who can strengthen the capabilities of our research teams.

Our Company: “We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world’s leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges”.

We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.

We offer a competitive salary and a progressive and comprehensive suite of employee benefits.
We offer state of the art working environment on site.
We offer the opportunity for growth and development and will support funding for relevant training and development programmes.

Why Should You Apply?

This is an opportunity for you as an Associate Principal Scientist - DMPK professional to make a real impact in a highly scientific and regulated environment, demonstrate leadership, ambition and the desire to grow with the department.
Build and shape your career in an environment that sets and commits to the highest standards.
To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do.

Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal, and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development. With operations in China, US and UK staffed by over 19,000 employees, Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan, and China.